Fosamax needs a break

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From: denvernaturopathic
Date: Mon, Feb 8, 2010 at 1:00 PM
Subject: Fosamax needs a break
To: drjeannd@gmail.com

Fosamax Needs a Break: Donโ€™t use this drug for more than five years
Jacob Schor, ND, FABNO
February 2009


The drugs that have been used with apparent success to treat
osteoporosis may now be a problem. ย Alendronate may weaken bone and
lead to increased fracture risk.

[a referenced version of this article is posted at:
http://denvernaturopathic.com/fosamaxBreak.htm]

Alendronate is the drug we know as Fosamax. ย It belongs to a class of
drugs called ย Bisphosphonates. ย These chemicals were developed in the
19th century but were not ย investigated until the 1960s for use in
disorders of bone metabolism. Their non-medical use was to soften
water in irrigation systems used in orange groves. The rationale for
giving them to people is that they prevent the dissolution of
hydroxylapatite, the principal bone mineral, so stopping bone loss.
Only in the 1990s was their actual mechanism of action explained when
Merck brought Fosamax to the market place.

There is little doubt that these drugs do what they are supposed to
over the short term: they increase bone density and decrease fracture
risk.

The FOSIT study published in 1999 told us this quite clearly. This
study reported on 1,908 ย healthy, postmenopausal women with
osteoporosis, 950 of whom ย took either 10 mg of Fosamax for a year,
while the other 958 got a placebo. ย Both groups took 500 mg of calcium
per day. ย After a year, bone mineral density increased by almost 5% on
average in those taking the Fosamax compared to the placebo group.
Non-spinal fractures decreased. Of those taking the drug only 19
suffered fractures compared to 37 of those taking placebo.

From the first use of these drugs, there was always a theoretical
worry. ย Recall that there are two main processes that occur constantly
in the bone: osteoclastic activity that breaks down old bone, and
osteoblastic activity that builds up new bone. ย This constant turnover
of bone maintains healthy and strong bone. ย These drugs stop the
osteoclastic activity so that the old bone is left untouched. ย This
increases bone density measurements. ย The worry was that because these
drugs halt normal bone turnover people using them would end up with
dense but more brittle bones. ย As the early studies consistently
showed a rapid reduction in fracture rates, this concern faded.

These early worries unfortunately were not ย just a product of
naturopathic paranoia; the problems just took a few years to show up.
The May/June 2008 issue of The Journal of Orthopaedic Trauma published
a report on โ€œLow-energy femoral shaft fractures associated with
alendronate use.โ€ ย The authors reviewed records of 70 patients who had
sustained low energy femur fractures. ย That means their femurs broke
without any major stress. ย Rather they did little things such as
walking or stepped off a curb and thus triggered the breaks. ย These
werenโ€™t young people, their average age was about 75. ย Of these 70
patients, 25 of them, a little over a third ย (36%), were taking
Fosamax. ย Nineteen (76%) of those 25 patients demonstrated a simple,
transverse fracture with a unicortical beak in an area of cortical
hypertrophy. ย This is a rare and peculiar type of fracture. ย Only 1
patient of those not taking Fossamax (2%) had this kind of bone break.
ย When the statistics were worked out, the numbers tell us that Fosamax
use significantly increased risk of these fractures: the odds ratio
was 139.33, 95% CI [19.0-939.4], P 0.0001). ย  You can say those taking Fosamax were about 140 times more
likely to get one of these rare fractures. ย It took about 7 years for
this problem to occur. ย Those taking Fosamax less than 2.5 years were
not at greater risk.

ย A 2009 paper in Geriatrics continued this story. ย It tells us that,
โ€œThe fractures are often preceded by pain in the affected thighโ€ฆโ€ this
paper suggests that patients not take Fosamax for longer than five
years. ย  ย Another 2009 article, this one in Clinical Calcium, echoed
this warning and suggested that, โ€œโ€ฆ alendronate treatment might be
stopped for a while after 5 years to prevent [these kinds of]โ€ฆ
fractures.โ€

Take a break to prevent a break might become a safety slogan.

Researcher from Johns Hopkins repeated this same story in the journal
Orthopedics in August 2009. ย  ย  Then just last November, 2009, doctors
from New York University report on seven different patients who had
broken both legs. The average age of these patients was 61 years and
on average they had taken Fosmax for 8.6 years. ย One patient had
broken both legs simultaneously. The article suggests ย that we start
checking the โ€˜good legโ€™ when people who have been taking Fosamax
sustain a suspicious fracture. ย If a problem is seen, they suggest
prophylactic repair.

Few doctors and fewer patients are paying attention to duration of
Fosamax use. ย Most patients will report theyโ€™ve taken Fosamax, โ€œfor
awhile.โ€ ย We need to start spreading the message, โ€œfor awhileโ€ should
be less than five years.
In our practice we are suggesting a break from use after a shorter
period of time, about three years. ย Discontinuing Fosamax use and
relying solely on naturopathic treatments even for an interval of
time, may, in the long run prove to be a safer course of action.

Unfortunately over the years as Fosamax was used with apparent benefit
by so many people, many of us grew lax, thinking that our early
worries were unfounded. ย In hindsight this may have been a problem all
along. ย Itโ€™s only in the last few years that enough patients have
taken the drug long enough that we can actually see the results of
long term bone suppression.


................................................................


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Fwd:HBD wins a Silver Medal!

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FOR IMMEDIATE RELEASE: February 4, 2010

Contact: Heather Manley, N.D.
Email: drheather@drheathernd.com
Phone: 808.640.1159

 

THE MOM’S CHOICE AWARDS® NAMES

HUMAN BODY DETECTIVES: THE LUCKY ESCAPE

  SILVER MEDALIST IN FAMILY-FRIENDLY PRODUCTS

  

The Mom's Choice Awards® has named Human Body Detectives: The Lucky Escape among the best in family friendly media, products and services by awarding them with silver medal in Juvenile Books (Level 1 - Ages 5 to 8) in Multimedia Experiences.

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Human Body Detectives is a series of educational adventure story-telling audio CDs and activity workbooks featuring Merrin and Pearl, sisters who find they have the magical ability to enter different systems in other people's bodies to solve health mysteries. Through the action- packed fictional adventures, listeners learn how the various systems work and what best foods fuel that system. The accompanying workbook filled with games and puzzles reinforces what they kids have learned and helps them further understand the importance of maintaining a healthy body.

The Mom’s Choice Awards® (MCA) is an awards program that recognizes authors, inventors, companies, parents and others for their efforts in creating quality family-friendly media, products and services. The Mom’s Choice Awards® seal helps families and educators navigate the vast array of products and services and make informed decisions.

An esteemed panel of judges includes education, media and other experts as well as parents, children, librarians, performing artists, producers, medical and business professionals, authors, scientists and others. A sampling of our panel members includes: Dr. Twila C. Liggett, ten-time Emmy-winner, professor and founder of PBS’s Reading Rainbow; Julie Aigner-Clark, Creator of Baby Einstein and The Safe Side Project; Jodee Blanco, New York Times best-selling author, Priscilla Dunstan, creator of the Dunstan Baby Language; Patricia Rossi, host of NBC’s Manners Minute; Dr. Letitia S. Wright, D.C., host of the Wright Place™ TV Show; and Catherine Witcher, M.Ed., special needs expert and founder of Precision Education, Inc.
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The evaluation process uses a propriety methodology in which entries are scored on a number of elements including production quality, design, educational value, entertainment value, originality, appeal and cost. The end result is a list of the best in family-friendly media, products and services that parents and educators can feel confident in using.

Follow Merrin and Pearl through their imaginative adventures in the digestive system , The Lucky Escape, the immune system, Battle with the Bugs and their newest, releasing in the Spring, The Heart Pumping Adventure.

For more information about HBD in the news please visit Human Body Detectives.

 

Contact us for more information on how the Human Body Detectives is used in educational programming.

 

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Dr. Manley is a naturopathic physician licensed in the state of Hawaii. She is a member of the American Association of Naturopathic Medicine and the Hawaii Naturopathic Medicine Association.  For more information, please visit www.drheathernd.com and www.humanbodydetectives.com, email drheather@drheathernd.com, or call 808-640-1159.

Dr. Heather ND: A Natural Resource - Dr. Heather’s site is a resource for people, especially parents, to learn about preventative healthcare. Dr. Heather believes everyone has a right to solid, natural, preventative healthcare information, and become proactive and confidant in their own family’s health.

 

 


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Health Risks Brochure - Institute for Responsible Technology

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GMO Health Risks Brochure

Genetically modified foods:

     YES, youโ€™re eating them. 
     NO, theyโ€™re not safe.

Did you know... since 1996 Americans have been eating genetically modified (GM) ingredients in most processed foods.

Did you know... GM plants, such as soybean, corn, cottonseed, and canola, have had foreign genes forced into their DNA. The inserted genes come from species, such as bacteria and viruses, which have never been in the human food supply.

Did you know... The American Academy of Environmental Medicine states, โ€œSeveral animal studies indicate serious health risks associated with GM food,โ€ including infertility, immune problems, accelerated aging, faulty insulin regulation, and changes in major organs and the gastrointestinal system. They ask physicians to advise patients to avoid GM foods.1

Find out what the risks are and start protecting yourself and your family today!

Why isnโ€™t the FDA protecting us?

In 1992, the Food and Drug Administration claimed they had no information showing that GM foods were substantially different from conventionally grown foods. Therefore they are safe to eat, and absolutely no safety studies were required. But internal memos made public by a lawsuit2 reveal that their position was staged by political appointees who were under orders from the White House to promote GMOs. In addition, the FDA official in charge of creating this policy was Michael Taylor, the former attorney for Monsanto, the largest biotech company, and later their vice president.

In reality, FDA scientists had repeatedly warned that GM foods can create unpredictable, hard-to-detect side effects, including allergies, toxins, new diseases, and nutritional problems. They urged long-term safety studies, but were ignored. 

Today, the same biotech companies who have been found guilty of hiding toxic effects of their chemical products are in charge of determining whether their GM foods are safe. Industry-funded GMO safety studies are too superficial to find most of the potential dangers, and their voluntary consultations with the FDA are widely criticized as a meaningless faรงade.3

Genetic modification is radically different from natural breeding

Genetic engineering transfers genes across natural species barriers. It uses imprecise laboratory techniques that bear no resemblance to natural breeding, and is based on outdated concepts of how genes and cells work.4 Gene insertion is done either by shooting genes from a โ€œgene gunโ€ into a plate of cells or by using bacteria to invade the cell with foreign DNA. The altered cell is then cloned into a plant.

Widespread, unpredictable changes

The genetic engineering process creates massive collateral damage, causing mutations in hundreds or thousands of locations throughout the plantโ€™s DNA.5 Natural genes can be deleted or permanently turned on or off, and hundreds may change their behavior.6 Even the inserted gene can be damaged or rearranged,7 and may create proteins that can trigger allergies or promote disease.

GM foods on the market

There are eight GM food crops. The five major varietiesโ€”soy, corn, canola, cotton, and sugar beetsโ€”have bacterial genes inserted, which allow the plants to survive an otherwise deadly dose of weed killer. Farmers use considerably more herbicides on these GM crops and so the food has higher herbicide residues. About 68% of GM crops are herbicide tolerant.

The second GM trait is a built-in pesticide, found in GM corn and cotton. A gene from the soil bacterium called Bt (for Bacillus thuringiensis) is inserted into the plantโ€™s DNA, where it secretes the insect-killing Bt-toxin in every cell. About 19% of GM crops produce their own pesticide. Another 13% produce a pesticide and are herbicide tolerant.

There is also Hawaiian papaya and a small amount of zucchini and yellow crookneck squash, which are engineered to resist a plant virus.

Growing evidence of harm from GMOs

GM soy and allergic reactions

  • Soy allergies skyrocketed by 50% in the UK, soon after GM soy was introduced.8
  • A skin prick allergy test shows that some people react to GM soy, but not to natural soy.9
  • Cooked GM soy contains as much as 7-times the amount of a known soy allergen.10
  •   GM soy also contains a new unexpected allergen, not found in natural soy.11

Bt corn and cotton linked to allergies

 

The biotech industry claims that Bt-toxin is harmless to humans and mammals because the natural bacteria version has been used as a spray by farmers for years. In reality, hundreds of people exposed to Bt spray had allergic-type symptoms,12 and mice fed Bt had powerful immune responses13 and damaged intestines.14 Moreover, the Bt in GM crops is designed to be more toxic than the natural spray and is thousands of times more concentrated.

Farm workers throughout India are getting the same allergic reactions from handling Bt cotton15 as those who reacted to Bt spray.16 Mice17 and rats18 fed Bt corn also showed immune responses.

GMOs fail allergy tests

No tests can guarantee that a GMO will not cause allergies. Although the World Health Organization recommends a screening protocol,19 the GM soy, corn, and papaya in our food supply fail those testsโ€”because their GM proteins have properties of known allergens.20

GMOs may make you allergic to non-GM foods

  • GM soy drastically reduces digestive enzymes in mice.21 If it also impairs your digestion, you may become sensitive and allergic to a variety of foods.
  • Mice fed Bt-toxin started having immune reactions to formerly harmless foods.22
  • Mice fed experimental GM peas also started reacting to a range of other foods.23 (The peas had already passed all the allergy tests normally done before a GMO gets on the market. Only this advanced test, which is never used on the GMOs we eat, revealed that the peas could actually be deadly.

GMOs and liver problems

  • Rats fed GM potatoes had smaller, partially atrophied livers.24
  • The livers of rats fed GM canola were 12-16% heavier.25
  • GM soy altered mouse liver cells in ways that suggest a toxic insult.26 The changes reversed after they switched to non-GM soy.27

GMOs, reproductive problems, and infant mortality

  • More than half the babies of mother rats fed GM soy died within three weeks.28
  • Male rats29 and mice30 fed GM soy had changed testicles, including altered young sperm cells in the mice.
  • The DNA of mouse embryos functioned differently when their parents ate GM soy31
  • Your browser may not support display of this image. The longer mice were fed GM corn, the less babies they had, and the smaller their babies were.32

Babies of female rats fed GM soy were considerably smaller, and more than half died within three weeks (compared to 10% of the 
non-GM soy controls).33    

Bt crops linked to sterility, disease, and death

  • Thousands of sheep, buffalo, and goats in India died after grazing on Bt cotton plants after harvest. Others suffered poor health and reproductive problems.34
  • Farmers in Europe and Asia say that cows, water buffaloes, chickens, and horses died from eating Bt corn varieties.35
  • About two dozen US farmers report that Bt corn varieties caused widespread sterility in pigs or cows.36
  • Filipinos in at least five villages fell sick when a nearby Bt corn variety was pollinating.37
  • Your browser may not support display of this image.

The stomach lining of rats fed GM potatoes showed excessive cell growth, a condition that may lead to cancer. Rats also had damaged organs and immune systems.38 

Functioning GM genes remain inside you

Unlike safety evaluations for drugs, there are no human clinical trials of GM foods. The only published human feeding experiment revealed that the genetic material inserted into GM soy transfers into bacteria living inside our intestines and continues to function.39 This means that long after we stop eating GM foods, we may still have their GM proteins produced continuously inside us.

  • If the antibiotic gene inserted into most GM crops were to transfer, it could create super diseases, resistant to antibiotics.
  • If the gene that creates Bt-toxin in GM corn were to transfer, it might turn our intestinal bacteria into living pesticide factories.
  • Animal studies show that DNA in food can travel into organs throughout the body, even into the fetus.40 

GM food supplement caused deadly epidemic

In the 1980s, a contaminated brand of a food supplement called L-tryptophan killed about 100 Americans and caused sickness and disability in another 5,000-10,000 people. The source of contaminants was almost certainly the genetic engineering process used in its production.41 The disease took years to find and was almost overlooked. It was only identified because the symptoms were unique, acute, and fast-acting. If all three characteristics were not in place, the deadly GM supplement might never have been identified or removed.

If GM foods on the market are causing common diseases or if their effects appear only after long-term exposure, we may not be able to identify the source of the problem for decades, if at all. There is no monitoring of GMO-related illnesses and no long-term animal studies. Heavily invested biotech corporations are gambling with the health of our nation for their profit.

Help end the genetic engineering of our food supply

When the tipping point of consumer concern about GMOs was achieved in Europe in 1999, within a single week virtually all major food manufacturers committed to remove GM ingredients. The Campaign for Healthier Eating in America is designed to reach a similar tipping point in the US soon.

Our growing network of manufacturers, retailers, healthcare practitioners, organizations, and the media, is informing consumers of the health risks of GMOs and helping them select healthier non-GMO alternatives with our Non-GMO Shopping Guides.

Go to www.responsibletechnology.org to get involved and learn how to avoid GMOs.

Start buying non-GMO today.

Help us stop the genetic engineering of our food supply.

Membership

Membership in our Campaign for Healthier Eating in America is free; Contributing members receive a free educational gift. Donations to the Institute For Responsible Technology are tax-deductible.

There are three ways to become a member or make a donation:

By mail:

Institute For Responsible Technology 
P.O. Box 469, Fairfield, IA 52556

Online:

www.ResponsibleTechnology.org 

By phone:

(641) 209-1765

The health information is from the book Genetic Roulette: The Documented Health Risk of Genetically Engineered Foods, by Jeffrey M. Smith.  

ยฉ copyright Institute For Responsible Technology 2008

The Institute is a fully tax deductible project of The Coordinating Council, a 501c(3).

Download your free Non-GMO Shopping Guide at www.ResponsibleTechnology.org 

[1] See www.biointegrity.org

[2] See Part 2, Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA 2007

[3] See for example 233-236, chart of disproved assumptions, in Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA 2007

[4] J. R. Latham, et al., โ€œThe Mutational Consequences of Plant Transformation,โ€ The Journal of Biomedicine and Biotechnology 2006, Article ID 25376: 1-7; see also Allison Wilson, et. al., โ€œTransformation-induced mutations in transgenic plants: Analysis and biosafety implications,โ€ Biotechnology and Genetic Engineering Reviews โ€“ Vol. 23, December 2006.

[5] Srivastava, et al, โ€œPharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis,โ€ Mol Med. 5, no. 11(Nov 1999):753โ€“67.

[6] Latham et al, โ€œThe Mutational Consequences of Plant Transformation, Journal of Biomedicine and Biotechnology 2006:1-7, article ID 25376, http://www.hindawi.com/journals/JBB/index.html; Draft risk analysis report application A378, Food derived from glyphosate-tolerant sugarbeet line 77 (GTSB77),โ€ ANZFA, March 7, 2001, www.agbios.com/docroot/decdocs/anzfa_gtsb77.pdf; E. Levine et al., โ€œMolecular Characterization of Insect Protected Corn Line MON 810.โ€ Unpublished study submitted to the EPA by Monsanto, EPA MRID No. 436655-01C (1995); Allison Wilson, PhD, Jonathan Latham, PhD, and Ricarda Steinbrecher, PhD, โ€œGenome Scramblingโ€”Myth or Reality? Transformation-Induced Mutations in Transgenic Crop Plants Technical Reportโ€”October 2004,โ€ www.econexus.info; C. Collonier, G. Berthier, F. Boyer, M. N. Duplan, S. Fernandez, N. Kebdani, A. Kobilinsky, M. Romanuk, Y. Bertheau, โ€œCharacterization of commercial GMO inserts: a source of useful material to study genome fluidity,โ€ Poster presented at ICPMB: International Congress for Plant Molecular Biology (nยฐVII), Barcelona, 23-28th June 2003. Poster courtesy of Dr. Gilles-Eric Seralini, Prรฉsident du Conseil Scientifique du CRII-GEN, www.crii-gen.org; also โ€œTransgenic lines proven unstableโ€ by Mae-Wan Ho, ISIS Report, 23 October 2003, www.i-sis.org.uk

[7] Netherwood et al, โ€œAssessing the survival of transgenic plant DNA in the human gastrointestinal tract,โ€ Nature Biotechnology 22 (2004): 2; Chowdhury, et al, โ€œDetection of genetically modified maize DNA fragments in the intestinal contents of pigs fed StarLink CBH351,โ€ Vet Hum Toxicol. 45 , no. 2 (March 2003): 95โ€“6; P. A. Chambers, et al, โ€œThe fate of antibiotic resistance marker genes in transgenic plant feed material fed to chickens,โ€ J. Antimic. Chemother. 49 (2000): 161โ€“164; and Paula S. Duggan, et al, โ€œFate of genetically modified maize DNA in the oral cavity and rumen of sheep,โ€ Br J Nutr. 89, no 2 (Feb.2003): 159โ€“66.

[8] Mark Townsend, โ€œWhy soya is a hidden destroyer,โ€ Daily Express, March 12, 1999.

[9] Hye-Yung Yum, Soo-Young Lee, Kyung-Eun Lee, Myung-Hyun Sohn, Kyu-Earn Kim, โ€œGenetically Modified and Wild Soybeans: An immunologic comparison,โ€ Allergy and Asthma Proceedings 26, no. 3 (Mayโ€“June 2005): 210-216(7).

[10] A. Pusztai and S. Bardocz, โ€œGMO in animal nutrition: potential benefits and risks,โ€ Chapter 17, Biology of Nutrition in Growing Animals, R. Mosenthin, J. Zentek and T. Zebrowska (Eds.) Elsevier, October 2005.

[11] Hye-Yung Yum, Soo-Young Lee, Kyung-Eun Lee, Myung-Hyun Sohn, Kyu-Earn Kim, โ€œGenetically Modified and Wild Soybeans: An immunologic comparison,โ€ Allergy and Asthma Proceedings 26, no. 3 (Mayโ€“June 2005): 210-216(7).

[12] M. Green, et al., โ€œPublic health implications of the microbial pesticide Bacillus thuringiensis: An epidemiological study, Oregon, 1985-86,โ€ Amer. J. Public Health 80, no. 7(1990): 848โ€“852; and M.A. Noble, P.D. Riben, and G. J. Cook, Microbiological and epidemiological surveillance program to monitor the health effects of Foray 48B BTK spray (Vancouver, B.C.: Ministry of Forests, Province of British Columbi, Sep. 30, 1992)

[13] Vazquez et al, โ€œIntragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice,โ€ 1897โ€“1912; Vazquez et al, โ€œCharacterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice,โ€ Brazilian Journal of Medical and Biological Research 33 (2000): 147โ€“155; and Vazquez et al, โ€œBacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant,โ€ Scandanavian Journal of Immunology 49 (1999): 578โ€“584. See also Vazquez-Padron et al., 147 (2000b).

[14] Nagui H. Fares, Adel K. El-Sayed, โ€œFine Structural Changes in the Ileum of Mice Fed on Endotoxin Treated Potatoes and Transgenic Potatoes,โ€ Natural Toxins 6, no. 6 (1998): 219โ€“233.

[15] See for example โ€œBt cotton causing allergic reaction in MP; cattle dead,โ€ Bhopal, Nov. 23, 2005, http://news.webindia123.com/news/showdetails.asp?id=170692&cat=Health;

[16] Ashish Gupta et. al., โ€œImpact of Bt Cotton on Farmersโ€™ Health (in Barwani and Dhar District of Madhya Pradesh),โ€ Investigation Report, Octโ€“Dec 2005; and M. Green, et al., โ€œPublic health implications of the microbial pesticide Bacillus thuringiensis: An epidemiological study, Oregon, 1985-86,โ€ Amer. J. Public Health 80, no. 7(1990): 848โ€“852; and M.A. Noble, P.D. Riben, and G. J. Cook, Microbiological and epidemiological surveillance program to monitor the health effects of Foray 48B BTK spray (Vancouver, B.C.: Ministry of Forests, Province of British Columbi, Sep. 30, 1992)

[17] FAO-WHO, โ€œEvaluation of Allergenicity of Genetically Modified Foods. Report of a Joint FAO/WHO Expert

Consultation on Allergenicity of Foods Derived from Biotechnology,โ€ Jan. 22โ€“25, 2001; http://www.fao.org/es/ESN/food/pdf/allergygm.pdf

[18] Gendel, โ€œThe use of amino acid sequence alignments to assess potential allergenicity of proteins used in genetically modified foods,โ€ Advances in Food and Nutrition Research 42 (1998), 45โ€“62; G. A. Kleter and A. A. C. M. Peijnenburg, โ€œScreening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences indentical to potential, IgE-binding linear epitopes of allergens,โ€ BMC Structural Biology 2 (2002): 8โ€“19; H. P. J. M. Noteborn, โ€œAssessment of the Stability to Digestion and Bioavailability of the LYS Mutant Cry9C Protein from Bacillus thuringiensis serovar tolworthi,โ€ Unpublished study submitted to the EPA by AgrEvo, EPA MRID No. 447343-05 (1998); and H. P. J. M. Noteborn et al, โ€œSafety Assessment of the Bacillus thuringiensis Insecticidal Crystal Protein CRYIA(b) Expressed in Transgenic Tomatoes,โ€ in Genetically modified foods: safety issues, American Chemical Society Symposium Series 605, eds. K.H. Engel et al., (Washington, DC, 1995): 134โ€“47.

[19] M. Malatesta, M. Biggiogera, E. Manuali, M. B. L. Rocchi, B. Baldelli, G. Gazzanelli, โ€œFine Structural Analyses of Pancreatic Acinar Cell Nuclei from Mice Fed on GM Soybean,โ€ Eur J Histochem 47 (2003): 385โ€“388.

[20] Vazquez et al, โ€œBacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant,โ€ Scandanavian Journal of Immunology 49 (1999): 578โ€“584. See also Vazquez-Padron et al., 147 (2000b).

[21] V. E. Prescott, et al, โ€œTransgenic Expression of Bean r-Amylase Inhibitor in Peas Results in Altered Structure and Immunogenicity,โ€ Journal of Agricultural Food Chemistry (2005): 53.

[22] Arpad Pusztai, โ€œCan science give us the tools for recognizing possible health risks of GM food,โ€ Nutrition and Health, 2002, Vol 16 Pp 73-84

[23] Comments to ANZFA about Applications A346, A362 and A363 from the Food Legislation and Regulation Advisory Group (FLRAG) of the Public Health Association of Australia (PHAA) on behalf of the PHAA, โ€œFood produced from glyphosate-tolerant canola line GT73,โ€ http://www.iher.org.au/

[24] M. Malatesta, C. Caporaloni, S. Gavaudan, M. B. Rocchi, S. Serafini, C. Tiberi, G. Gazzanelli, โ€œUltrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean,โ€ Cell Struct Funct. 27 (2002): 173โ€“180.

[25] M. Malatesta, C. Tiberi, B. Baldelli, S. Battistelli, E. Manuali, M. Biggiogera, โ€œReversibility of Hepatocyte Nuclear Modifications in Mice Fed on Genetically Modified Soybean,โ€ Eur J Histochem, 49 (2005): 237-242.

[26] I.V. Ermakova, โ€œDiet with the Soya Modified by Gene EPSPS CP4 Leads to Anxiety and Aggression in Rats,โ€ 14th European Congress of Psychiatry. Nice, France, March 4-8, 2006; โ€œGenetically modified soy affects posterity: Results of Russian scientistsโ€™ studies,โ€ REGNUM, October 12, 2005; http://www.regnum.ru/english/526651.html;  Irina Ermakova, โ€œGenetically modified soy leads to the decrease of weight and high mortality of rat pups of the first generation. Preliminary studies,โ€ Ecosinform 1 (2006): 4โ€“9.

[27] Irina Ermakova, โ€œExperimental Evidence of GMO Hazards,โ€ Presentation at Scientists for a GM Free Europe, EU Parliament, Brussels, June 12, 2007

[28] L. Vecchio et al, โ€œUltrastructural Analysis of Testes from Mice Fed on Genetically Modified Soybean,โ€ European Journal of Histochemistry 48, no. 4 (Octโ€“Dec 2004):449โ€“454.

[29] Oliveri et al., โ€œTemporary Depression of Transcription in Mouse Pre-implantion Embryos from Mice Fed on Genetically Modified Soybean,โ€ 48th Symposium of the Society for Histochemistry, Lake Maggiore (Italy), September 7โ€“10, 2006.

[30] I.V. Ermakova, โ€œDiet with the Soya Modified by Gene EPSPS CP4 Leads to Anxiety and Aggression in Rats,โ€ 14th

European Congress of Psychiatry. Nice, France, March 4-8, 2006; โ€œGenetically modified soy affects posterity: Results of Russian scientistsโ€™ studies,โ€ REGNUM, October 12, 2005; http://www.regnum.ru/english/526651.html;  Irina Ermakova, โ€œGenetically modified soy leads to the decrease of weight and high mortality of rat pups of the first generation. Preliminary studies,โ€ Ecosinform 1 (2006): 4โ€“9.

[31] โ€œMortality in Sheep Flocks after Grazing on Bt Cotton Fieldsโ€”Warangal District, Andhra Pradeshโ€ Report of the Preliminary Assessment, April 2006, http://www.gmwatch.org/archive2.asp?arcid=6494

[32] Mae-Wan Ho, โ€œGM Ban Long Overdue, Dozens Ill & Five Deaths in the Philippines,โ€ ISIS Press Release, June 2, 2006; and Mae-Wan Ho and Sam Burcher, โ€œCows Ate GM Maize & Died,โ€ ISIS Press Release, January 13, 2004, http://www.isis.org.uk/CAGMMAD.php

[33] Personal communication with Jerry Rosman and other farmers, 2006; also reported widely in the farm press.

[34] See for example Mae-Wan Ho, โ€œGM Ban Long Overdue, Dozens Ill & Five Deaths in the Philippines,โ€ ISIS Press Release, June 2, 2006; โ€œStudy Result Not Final, Proof Bt Corn Harmful to Farmers,โ€ BusinessWorld, 02 Mar 2004; and โ€œGenetically Modified Crops and Illness Linked,โ€ Manila Bulletin, 04 Mar 2004.

[35] Arpad Pusztai, โ€œCan science give us the tools for recognizing possible health risks of GM food,โ€ Nutrition and Health, 2002, Vol 16 Pp 73-84; Stanley W. B. Ewen and Arpad Pusztai, โ€œEffect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine,โ€ Lancet, 1999 Oct 16; 354 (9187): 1353-4; and Arpad Pusztai, โ€œFacts Behind the GM Pea Controversy: Epigenetics, Transgenic Plants & Risk Assessment,โ€ Proceedings of the Conference, December 1st 2005 (Frankfurtam Main, Germany: Literaturhaus, 2005)

[36] Netherwood et al, โ€œAssessing the survival of transgenic plant DNA in the human gastrointestinal tract,โ€ Nature Biotechnology 22 (2004): 2.

[37] Ricarda A. Steinbrecher and Jonathan R. Latham, โ€œHorizontal gene transfer from GM crops to unrelated organisms,โ€ GM Science Review Meeting of the Royal Society of Edinburgh on โ€œGM Gene Flow: Scale and Consequences for Agriculture and the Environment,โ€ January 27, 2003; Traavik and Heinemann, Genetic Engineering and Omitted Health Research; citing Schubbert, et al, โ€œIngested foreign (phage M13) DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice,โ€ Mol Gen Genet. 242, no. 5 (1994): 495โ€“504; Schubbert et al, โ€œForeign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA,โ€ Proc Natl Acad Sci USA 94, no. 3 (1997): 961โ€“6; Schubbert et al, โ€œOn the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus,โ€ Mol Gen Genet. 259, no. 6 (1998): 569โ€“76; Hohlweg and Doerfler, โ€œOn the fate of plants or other foreign genes upon the uptake in food or after intramuscular injection in mice,โ€ Mol Genet Genomics 265 (2001): 225โ€“233; Palka-Santani, et al., โ€œThe gastrointestinal tract as the portal of entry for foreign macromolecules: fate of DNA and proteins,โ€ Mol Gen Genomics 270 (2003): 201โ€“215; Einspanier, et al, โ€œThe fate of forage plant DNA in farm animals; a collaborative case-study investigating cattle and chicken fed recombinant plant material,โ€ Eur Food Res Technol 212 (2001): 129โ€“134; Klotz, et al, โ€œDegradation and possible carry over of feed DNA monitored in pigs and poultry,โ€ Eur Food Res Technol 214 (2002): 271โ€“275; Forsman, et al, โ€œUptake of amplifiable fragments of retrotransposon DNA from the human alimentary tract,โ€ Mol Gen Genomics 270 (2003): 362โ€“368; Chen, et al, โ€œTransfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles,โ€ World Journal of Gastroenterology 10, no 1(2004): 112โ€“116; Phipps, et al, โ€œDetection of transgenic and endogenous plant DNA in rumen fluid, duodenal digesta, milk, blood, and feces of lactating dairy cows,โ€ J Dairy Sci. 86, no. 12(2003): 4070โ€“8.

[38] William E. Crist, Toxic L-tryptophan: Shedding Light on a Mysterious Epidemic, http://www.seedsofdeception.com/Public/L-tryptophan/index.cfm; and Jeffrey M. SmithSeeds of Deception, Yes! Books, Fairfield, IA 2003, chapter 4, Deadly Epidemic

 

Filed under  //  genetically modified foods   GMOs  
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Facebook | Healthy Child Healthy World: The Top 10 Toxic Products You Donโ€™t Need

It's become so common in our culture to assume we need things - a lot of things. Over-consumption is not only a strain on our bank accounts and environment, it can also be harmful to our health. Whether there's a warning label or not (usually not), many of the things we buy have associated health risks.

Here are ten toxic products, in no particular order, that you don't need. And, once you read about them, you probably won't want them either. Be aware that different homes may have different products that are more toxic than these. This is just a basic list of some of the most commonly purchased products that are almost entirely unnecessary, but pose significant risks.

1. Air fresheners: Most air fresheners mask odors with a synthetic fragrance or numb your sense of smell with chemical anesthetics. But, they do nothing to eliminate the source of the odor. Also, aerosol air fresheners spew out tiny droplets of chemicals that are easily inhaled into the lungs. Instead, ventilate well and choose natural deodorizers, such as zeolite or baking soda, which contain minerals that absorb odors. How to Freshen Indoor Air Naturally includes recipes for other homemade remedies. Plants are also helpful for purifying your indoor air.

2. Drain, oven and toilet bowl cleaners: Yes, three products instead of one, but they all fit under the category of cleaners - and these are the three nastiest. Corrosive or caustic cleaners, such as the lye and acids found in drain cleaners, oven cleaners and acid-based toilet bowl cleaners, are the most dangerous cleaning products because they burn skin, eyes and internal tissue easily.

* To clean extra-greasy ovens, mix together 1 cup baking soda and 1/4 cup of washing soda, then add enough water to make a paste; apply the paste to oven surfaces and let soak overnight. The next morning, lift off soda mixture and grime; and rinse surfaces well.
* Prevent clogged drains by using hair and food traps.
* To de-grease and sweeten sink and tub drains, pour 1/2 cup of baking soda down drain followed by 1 cup vinegar; let bubble for 15 minutes; rinse with hot water. You might have to repeat the whole procedure more than once. This same mixture can be used prior to scrubbing your toilet bowl to deodorize and scour away grime.

3. Canned food: It's probably shocking to find a food item on a toxic product list, but it's no mistake. Food cans are lined with an epoxy resin that contains bisphenol-A (BPA). Most experts believe this is our main source of exposure to BPA, which has been linked to hormone disruption, obesity, heart disease, and much more. Eden Foods is currently the only company with BPA-free canned foods (other than the canned tomatoes, which they haven't found an adequate substitute for given the acidity of the tomatoes). Opt for fresh, frozen, dried or jarred foods.

4. Pesticides: This is a huge category of products, but they deserve inclusion in their entirety because of how extremely toxic they are. They're made to be. That's how they kill things. But, solving your pest problem may leave you with another problem - residual poisons that linger on surfaces, contaminate air, and get tracked onto carpet from the bottom of shoes. There are so many non-toxic ways to eliminate pests and weeds - next time you need to get on the offense, check out the recommendations at Beyond Pesticides.

5. Dry-cleaning: Okay, it's a service and not a product per se, but the chemical used to do it, perchloroethylene, has been linked to cancer as well as nervous system, kidney, liver and reproductive disorders. Even bringing dry-cleaned clothes home is risky. EPA studies have found that people who reported visiting a dry-cleaning shop showed twice as much perc in their breath, on average, as other people. EPA also found that levels of perc remained elevated in a home for as long as one week after placing newly dry-cleaned clothes in a closet. A Consumers Union study found that people who wear freshly dry-cleaned clothes, like a jacket and shirt, every week over a 40-year period, could inhale enough perc "to measurably increase their risk of cancer" - by as much as 150 times what is considered "negligible risk." Try wet-cleaning, CO2 technology, or even hand-washing.

6. Bottled water: Most people buy bottled water thinking they're avoiding any contaminants that may be present in their tap water. For the most part, they're wrong. Bottled water can be just as, or even more, contaminated than tap water. In fact, some bottled water IS tap water - just packaged (in plastic that can leach chemicals into the water) and over-priced. Also, from manufacture to disposal, bottled water creates an enormous amount of pollution - making our water even less drinkable. Do yourself and the world a favor and invest in a reusable stainless steel water bottle and a water filter.

7. Rubber duckies: How does such a cute toy end up on a toxic product list? When it's made from PVC - the poison plastic. Banned in over 14 countries and the European Union, PVC, also known as vinyl, is still legally sold by U.S. retailers although it threatens environmental and consumer health at every stage of its product life cycle, according to the Center for Health, Environment, and Justice (CHEJ). When it's in your home, PVC can leach phthalates (linked to hormone disruption) and lead (a potent neurotoxicant) - contaminating air, dust, and eventually you. Go PVC-free by reading packages and avoiding the #3 in the chasing arrows symbol (usually found on the bottom of a product). If a plastic is not labeled, call the manufacturer. Learn more.

8. Couch cushions: No, you needn't get rid of all your cushions and consign yourself to a future of discomfort. Just avoid cushions, pillows, and anything with foam labeled as meeting California TB 117, as it is likely to contain toxic fire retardants. These chemicals migrate from the foam to dust to people. In animal research, these chemicals are associated with cancer, birth defects, thyroid disruption, reproductive and neurological disorders such as hyperactivity and mental retardation. Don't worry about increasing your fire risk, data does not show that this standard has resulted in increased fire safety. Look for foam and cushions made with polyester, down, wool, or cotton as they are unlikely to contain toxic fire retardants.

9. Perfume and cologne: Colognes and perfumes may make us more attractive. But mixed in with the colors and scents are a wide variety of unattractive chemicals. Perfumes and fragrances can consist of hundreds of chemicals. Testing of Calvin Klein's Eternity by an independent lab, commissioned by Environmental Health Network (EHN), revealed that the perfume contained over 800 compounds. Among the chemicals of concern is diethyl phthalate (DEP) that is absorbed through the skin and can accumulate in human fat tissue. Phthalates are suspected carcinogens and hormone disruptors that are increasingly being linked to reproductive disorders.

It's not so simple to avoid phthalates by switching products because they are rarely listed on product ingredient labels. Phthalates are claimed as a part of trade secret formulas, and are exempt from federal labeling requirements. Find out if products you currently use contain phthalates and find safer ones on Environmental Working Group's Skin Deep Searchable Product Guide website.

10. Oil-based paints and finishes: There are 300 toxic chemicals and 150 carcinogens potentially present in oil-based paint, according to a John Hopkins University study. Still interested in coating your walls and furniture with this gunk? I hope not. Look for water-based options - ideally those that are low- or no-VOC. You could also explore natural finishes like milk paint and vegetable or wax based wood finishes.

 

 

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10 Questions for Author Michael Pollan - TIME

Michael Pollan

Alia Malley

Can you tell us what your current diet is? If it is not vegetarian, why not?

Scott Yanoff, MILWAUKEE

I still eat meat. But I eat a lot less. I have enormous respect for vegetarians, but I believe there are ways to eat meat that are good for you and good for the environment.

What's your guiltiest pleasure, and how do you rationalize it?

Kirsten Hagfors

KETCHUM, IDAHO

I like French fries, and I probably shouldn't eat them very often. I actually came up with a rule: Eat all the junk food you want as long as you cook it yourself. One reason we struggle with obesity today is that special-occasion foods like French fries, cakes and cookies have become so easy to obtain.

Do you think organic farming can be done on a large scale, bringing cost down closer to that of nonorganic foods?

Michael Lawrence, NASHVILLE

I think organic food will come down in price. But we need to pay people a living wage so they can afford to buy real food. In the 1970s, the rise of fast food paralleled the collapse of family wages. In a way, cheap food has subsidized that collapse. We have to rebuild those two.

Can small changes in American shopping and eating patterns make a difference collectively?

Judith Corr

GRAND RAPIDS, MICH.

Without question. Look, you get to vote with your fork three times a day. That's a lot more votes you have than in any other realm of life. Getting that vote right even once a day makes a difference.

How can consumers ensure a strong food system for future generations?

Brad Christian

MEMPHIS, TENN.

We need to vote with our forks as consumers. We also need to make our agricultural policies support the kind of food system we want--support farmers who are growing organic food or local food, not just big corn and soy farmers.

Are genetically modified crops harming our health?

Barbara Comnes, CHICAGO

The honest answer is, We don't know. There is a tremendous experiment being performed right now on humans and the environment with these crops, which are much less regulated than people realize. You should be able to decide if you want to eat genetically modified food. And we're not allowed to right now.

What can be done to end subsidies for agribusiness?

Kim Graves, CATSKILL, N.Y.

I don't agree that we need to eliminate subsidies. Government has been supporting farmers in one way or another since the Depression. There's been intervention in agriculture going back to the Old Testament. I think we should support our farmers, but we should get something more for it than cheap calories.

If you could change only one thing about our agricultural system, what would it be?

Scott Exo, PORTLAND, ORE.

I would bring animals back onto farms. We have seen a wholesale migration of animals to feedlots over the past 20 or 30 years. On a farm, their waste feeds the crops and the crops feed the animals--it's an elegant solution. When we took animals off the farms, we divided that solution into two big problems.

Filed under  //  Michael Pollan  
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Tartelette: Lemon Goat Cheese Cheesecakes With Blood Orange Sauce- Swoon!

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Gluten-Free Sausage Recall | NFCA

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Judge asked to halt planting of genetically modified sugarbeet seeds in Oregon

I don't think the public is taking this issue very seriously outside of a small group of very concerned people.

With the recent release of Monsanto's own data of genetically modified corn and subsequent analysis, it appears that such genetic modification of inserting pesticides into biological material could be detrimental to the organs of living animals that consume this food.

At the very least, GMO labels should be required. But the natural process of how these genetically modified plants can - and will - spread their genes, will result in the unintended spread of potentially dangerous genetic modifications, threatening our agricultural supply.

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Love these! and that Happy Owl Glassworks makes so many more animals too.

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