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GMO Health Risks Brochure
Genetically modified foods:
YES, youโre eating them.
NO, theyโre not safe.
Did you know... since 1996 Americans have been eating genetically modified (GM) ingredients in most processed foods.
Did you know... GM plants, such as soybean, corn, cottonseed, and canola, have had foreign genes forced into their DNA. The inserted genes come from species, such as bacteria and viruses, which have never been in the human food supply.
Did you know... The American Academy of Environmental Medicine states, โSeveral animal studies indicate serious health risks associated with GM food,โ including infertility, immune problems, accelerated aging, faulty insulin regulation, and changes in major organs and the gastrointestinal system. They ask physicians to advise patients to avoid GM foods.1
Find out what the risks are and start protecting yourself and your family today!
Why isnโt the FDA protecting us?
In 1992, the Food and Drug Administration claimed they had no information showing that GM foods were substantially different from conventionally grown foods. Therefore they are safe to eat, and absolutely no safety studies were required. But internal memos made public by a lawsuit2 reveal that their position was staged by political appointees who were under orders from the White House to promote GMOs. In addition, the FDA official in charge of creating this policy was Michael Taylor, the former attorney for Monsanto, the largest biotech company, and later their vice president.
In reality, FDA scientists had repeatedly warned that GM foods can create unpredictable, hard-to-detect side effects, including allergies, toxins, new diseases, and nutritional problems. They urged long-term safety studies, but were ignored.
Today, the same biotech companies who have been found guilty of hiding toxic effects of their chemical products are in charge of determining whether their GM foods are safe. Industry-funded GMO safety studies are too superficial to find most of the potential dangers, and their voluntary consultations with the FDA are widely criticized as a meaningless faรงade.3
Genetic modification is radically different from natural breeding
Genetic engineering transfers genes across natural species barriers. It uses imprecise laboratory techniques that bear no resemblance to natural breeding, and is based on outdated concepts of how genes and cells work.4 Gene insertion is done either by shooting genes from a โgene gunโ into a plate of cells or by using bacteria to invade the cell with foreign DNA. The altered cell is then cloned into a plant.
Widespread, unpredictable changes
The genetic engineering process creates massive collateral damage, causing mutations in hundreds or thousands of locations throughout the plantโs DNA.5 Natural genes can be deleted or permanently turned on or off, and hundreds may change their behavior.6 Even the inserted gene can be damaged or rearranged,7 and may create proteins that can trigger allergies or promote disease.
GM foods on the market
There are eight GM food crops. The five major varietiesโsoy, corn, canola, cotton, and sugar beetsโhave bacterial genes inserted, which allow the plants to survive an otherwise deadly dose of weed killer. Farmers use considerably more herbicides on these GM crops and so the food has higher herbicide residues. About 68% of GM crops are herbicide tolerant.
The second GM trait is a built-in pesticide, found in GM corn and cotton. A gene from the soil bacterium called Bt (for Bacillus thuringiensis) is inserted into the plantโs DNA, where it secretes the insect-killing Bt-toxin in every cell. About 19% of GM crops produce their own pesticide. Another 13% produce a pesticide and are herbicide tolerant.
There is also Hawaiian papaya and a small amount of zucchini and yellow crookneck squash, which are engineered to resist a plant virus.
Growing evidence of harm from GMOs
GM soy and allergic reactions
- Soy allergies skyrocketed by 50% in the UK, soon after GM soy was introduced.8
- A skin prick allergy test shows that some people react to GM soy, but not to natural soy.9
- Cooked GM soy contains as much as 7-times the amount of a known soy allergen.10
- GM soy also contains a new unexpected allergen, not found in natural soy.11
Bt corn and cotton linked to allergies
The biotech industry claims that Bt-toxin is harmless to humans and mammals because the natural bacteria version has been used as a spray by farmers for years. In reality, hundreds of people exposed to Bt spray had allergic-type symptoms,12 and mice fed Bt had powerful immune responses13 and damaged intestines.14 Moreover, the Bt in GM crops is designed to be more toxic than the natural spray and is thousands of times more concentrated.
Farm workers throughout India are getting the same allergic reactions from handling Bt cotton15 as those who reacted to Bt spray.16 Mice17 and rats18 fed Bt corn also showed immune responses.
GMOs fail allergy tests
No tests can guarantee that a GMO will not cause allergies. Although the World Health Organization recommends a screening protocol,19 the GM soy, corn, and papaya in our food supply fail those testsโbecause their GM proteins have properties of known allergens.20
GMOs may make you allergic to non-GM foods
- GM soy drastically reduces digestive enzymes in mice.21 If it also impairs your digestion, you may become sensitive and allergic to a variety of foods.
- Mice fed Bt-toxin started having immune reactions to formerly harmless foods.22
- Mice fed experimental GM peas also started reacting to a range of other foods.23 (The peas had already passed all the allergy tests normally done before a GMO gets on the market. Only this advanced test, which is never used on the GMOs we eat, revealed that the peas could actually be deadly.)
GMOs and liver problems
- Rats fed GM potatoes had smaller, partially atrophied livers.24
- The livers of rats fed GM canola were 12-16% heavier.25
- GM soy altered mouse liver cells in ways that suggest a toxic insult.26 The changes reversed after they switched to non-GM soy.27
GMOs, reproductive problems, and infant mortality
- More than half the babies of mother rats fed GM soy died within three weeks.28
- Male rats29 and mice30 fed GM soy had changed testicles, including altered young sperm cells in the mice.
- The DNA of mouse embryos functioned differently when their parents ate GM soy31
The longer mice were fed GM corn, the less babies they had, and the smaller their babies were.32
Babies of female rats fed GM soy were considerably smaller, and more than half died within three weeks (compared to 10% of the
non-GM soy controls).33
Bt crops linked to sterility, disease, and death
- Thousands of sheep, buffalo, and goats in India died after grazing on Bt cotton plants after harvest. Others suffered poor health and reproductive problems.34
- Farmers in Europe and Asia say that cows, water buffaloes, chickens, and horses died from eating Bt corn varieties.35
- About two dozen US farmers report that Bt corn varieties caused widespread sterility in pigs or cows.36
- Filipinos in at least five villages fell sick when a nearby Bt corn variety was pollinating.37

The stomach lining of rats fed GM potatoes showed excessive cell growth, a condition that may lead to cancer. Rats also had damaged organs and immune systems.38
Functioning GM genes remain inside you
Unlike safety evaluations for drugs, there are no human clinical trials of GM foods. The only published human feeding experiment revealed that the genetic material inserted into GM soy transfers into bacteria living inside our intestines and continues to function.39 This means that long after we stop eating GM foods, we may still have their GM proteins produced continuously inside us.
- If the antibiotic gene inserted into most GM crops were to transfer, it could create super diseases, resistant to antibiotics.
- If the gene that creates Bt-toxin in GM corn were to transfer, it might turn our intestinal bacteria into living pesticide factories.
- Animal studies show that DNA in food can travel into organs throughout the body, even into the fetus.40
GM food supplement caused deadly epidemic
In the 1980s, a contaminated brand of a food supplement called L-tryptophan killed about 100 Americans and caused sickness and disability in another 5,000-10,000 people. The source of contaminants was almost certainly the genetic engineering process used in its production.41 The disease took years to find and was almost overlooked. It was only identified because the symptoms were unique, acute, and fast-acting. If all three characteristics were not in place, the deadly GM supplement might never have been identified or removed.
If GM foods on the market are causing common diseases or if their effects appear only after long-term exposure, we may not be able to identify the source of the problem for decades, if at all. There is no monitoring of GMO-related illnesses and no long-term animal studies. Heavily invested biotech corporations are gambling with the health of our nation for their profit.
Help end the genetic engineering of our food supply
When the tipping point of consumer concern about GMOs was achieved in Europe in 1999, within a single week virtually all major food manufacturers committed to remove GM ingredients. The Campaign for Healthier Eating in America is designed to reach a similar tipping point in the US soon.
Our growing network of manufacturers, retailers, healthcare practitioners, organizations, and the media, is informing consumers of the health risks of GMOs and helping them select healthier non-GMO alternatives with our Non-GMO Shopping Guides.
Go to www.responsibletechnology.org to get involved and learn how to avoid GMOs.
Start buying non-GMO today.
Help us stop the genetic engineering of our food supply.
Membership
Membership in our Campaign for Healthier Eating in America is free; Contributing members receive a free educational gift. Donations to the Institute For Responsible Technology are tax-deductible.
There are three ways to become a member or make a donation:
By mail:
Institute For Responsible Technology
P.O. Box 469, Fairfield, IA 52556
Online:
www.ResponsibleTechnology.org
By phone:
(641) 209-1765
The health information is from the book Genetic Roulette: The Documented Health Risk of Genetically Engineered Foods, by Jeffrey M. Smith.
ยฉ copyright Institute For Responsible Technology 2008
The Institute is a fully tax deductible project of The Coordinating Council, a 501c(3).
Download your free Non-GMO Shopping Guide at www.ResponsibleTechnology.org
[1] See www.biointegrity.org
[2] See Part 2, Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA 2007
[3] See for example 233-236, chart of disproved assumptions, in Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods, Yes! Books, Fairfield, IA 2007
[4] J. R. Latham, et al., โThe Mutational Consequences of Plant Transformation,โ The Journal of Biomedicine and Biotechnology 2006, Article ID 25376: 1-7; see also Allison Wilson, et. al., โTransformation-induced mutations in transgenic plants: Analysis and biosafety implications,โ Biotechnology and Genetic Engineering Reviews โ Vol. 23, December 2006.
[5] Srivastava, et al, โPharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis,โ Mol Med. 5, no. 11(Nov 1999):753โ67.
[6] Latham et al, โThe Mutational Consequences of Plant Transformation, Journal of Biomedicine and Biotechnology 2006:1-7, article ID 25376, http://www.hindawi.com/journals/JBB/index.html; Draft risk analysis report application A378, Food derived from glyphosate-tolerant sugarbeet line 77 (GTSB77),โ ANZFA, March 7, 2001, www.agbios.com/docroot/decdocs/anzfa_gtsb77.pdf; E. Levine et al., โMolecular Characterization of Insect Protected Corn Line MON 810.โ Unpublished study submitted to the EPA by Monsanto, EPA MRID No. 436655-01C (1995); Allison Wilson, PhD, Jonathan Latham, PhD, and Ricarda Steinbrecher, PhD, โGenome ScramblingโMyth or Reality? Transformation-Induced Mutations in Transgenic Crop Plants Technical ReportโOctober 2004,โ www.econexus.info; C. Collonier, G. Berthier, F. Boyer, M. N. Duplan, S. Fernandez, N. Kebdani, A. Kobilinsky, M. Romanuk, Y. Bertheau, โCharacterization of commercial GMO inserts: a source of useful material to study genome fluidity,โ Poster presented at ICPMB: International Congress for Plant Molecular Biology (nยฐVII), Barcelona, 23-28th June 2003. Poster courtesy of Dr. Gilles-Eric Seralini, Prรฉsident du Conseil Scientifique du CRII-GEN, www.crii-gen.org; also โTransgenic lines proven unstableโ by Mae-Wan Ho, ISIS Report, 23 October 2003, www.i-sis.org.uk
[7] Netherwood et al, โAssessing the survival of transgenic plant DNA in the human gastrointestinal tract,โ Nature Biotechnology 22 (2004): 2; Chowdhury, et al, โDetection of genetically modified maize DNA fragments in the intestinal contents of pigs fed StarLink CBH351,โ Vet Hum Toxicol. 45 , no. 2 (March 2003): 95โ6; P. A. Chambers, et al, โThe fate of antibiotic resistance marker genes in transgenic plant feed material fed to chickens,โ J. Antimic. Chemother. 49 (2000): 161โ164; and Paula S. Duggan, et al, โFate of genetically modified maize DNA in the oral cavity and rumen of sheep,โ Br J Nutr. 89, no 2 (Feb.2003): 159โ66.
[8] Mark Townsend, โWhy soya is a hidden destroyer,โ Daily Express, March 12, 1999.
[9] Hye-Yung Yum, Soo-Young Lee, Kyung-Eun Lee, Myung-Hyun Sohn, Kyu-Earn Kim, โGenetically Modified and Wild Soybeans: An immunologic comparison,โ Allergy and Asthma Proceedings 26, no. 3 (MayโJune 2005): 210-216(7).
[10] A. Pusztai and S. Bardocz, โGMO in animal nutrition: potential benefits and risks,โ Chapter 17, Biology of Nutrition in Growing Animals, R. Mosenthin, J. Zentek and T. Zebrowska (Eds.) Elsevier, October 2005.
[11] Hye-Yung Yum, Soo-Young Lee, Kyung-Eun Lee, Myung-Hyun Sohn, Kyu-Earn Kim, โGenetically Modified and Wild Soybeans: An immunologic comparison,โ Allergy and Asthma Proceedings 26, no. 3 (MayโJune 2005): 210-216(7).
[12] M. Green, et al., โPublic health implications of the microbial pesticide Bacillus thuringiensis: An epidemiological study, Oregon, 1985-86,โ Amer. J. Public Health 80, no. 7(1990): 848โ852; and M.A. Noble, P.D. Riben, and G. J. Cook, Microbiological and epidemiological surveillance program to monitor the health effects of Foray 48B BTK spray (Vancouver, B.C.: Ministry of Forests, Province of British Columbi, Sep. 30, 1992)
[13] Vazquez et al, โIntragastric and intraperitoneal administration of Cry1Ac protoxin from Bacillus thuringiensis induces systemic and mucosal antibody responses in mice,โ 1897โ1912; Vazquez et al, โCharacterization of the mucosal and systemic immune response induced by Cry1Ac protein from Bacillus thuringiensis HD 73 in mice,โ Brazilian Journal of Medical and Biological Research 33 (2000): 147โ155; and Vazquez et al, โBacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant,โ Scandanavian Journal of Immunology 49 (1999): 578โ584. See also Vazquez-Padron et al., 147 (2000b).
[14] Nagui H. Fares, Adel K. El-Sayed, โFine Structural Changes in the Ileum of Mice Fed on Endotoxin Treated Potatoes and Transgenic Potatoes,โ Natural Toxins 6, no. 6 (1998): 219โ233.
[15] See for example โBt cotton causing allergic reaction in MP; cattle dead,โ Bhopal, Nov. 23, 2005, http://news.webindia123.com/news/showdetails.asp?id=170692&cat=Health;
[16] Ashish Gupta et. al., โImpact of Bt Cotton on Farmersโ Health (in Barwani and Dhar District of Madhya Pradesh),โ Investigation Report, OctโDec 2005; and M. Green, et al., โPublic health implications of the microbial pesticide Bacillus thuringiensis: An epidemiological study, Oregon, 1985-86,โ Amer. J. Public Health 80, no. 7(1990): 848โ852; and M.A. Noble, P.D. Riben, and G. J. Cook, Microbiological and epidemiological surveillance program to monitor the health effects of Foray 48B BTK spray (Vancouver, B.C.: Ministry of Forests, Province of British Columbi, Sep. 30, 1992)
[17] FAO-WHO, โEvaluation of Allergenicity of Genetically Modified Foods. Report of a Joint FAO/WHO Expert
Consultation on Allergenicity of Foods Derived from Biotechnology,โ Jan. 22โ25, 2001; http://www.fao.org/es/ESN/food/pdf/allergygm.pdf
[18] Gendel, โThe use of amino acid sequence alignments to assess potential allergenicity of proteins used in genetically modified foods,โ Advances in Food and Nutrition Research 42 (1998), 45โ62; G. A. Kleter and A. A. C. M. Peijnenburg, โScreening of transgenic proteins expressed in transgenic food crops for the presence of short amino acid sequences indentical to potential, IgE-binding linear epitopes of allergens,โ BMC Structural Biology 2 (2002): 8โ19; H. P. J. M. Noteborn, โAssessment of the Stability to Digestion and Bioavailability of the LYS Mutant Cry9C Protein from Bacillus thuringiensis serovar tolworthi,โ Unpublished study submitted to the EPA by AgrEvo, EPA MRID No. 447343-05 (1998); and H. P. J. M. Noteborn et al, โSafety Assessment of the Bacillus thuringiensis Insecticidal Crystal Protein CRYIA(b) Expressed in Transgenic Tomatoes,โ in Genetically modified foods: safety issues, American Chemical Society Symposium Series 605, eds. K.H. Engel et al., (Washington, DC, 1995): 134โ47.
[19] M. Malatesta, M. Biggiogera, E. Manuali, M. B. L. Rocchi, B. Baldelli, G. Gazzanelli, โFine Structural Analyses of Pancreatic Acinar Cell Nuclei from Mice Fed on GM Soybean,โ Eur J Histochem 47 (2003): 385โ388.
[20] Vazquez et al, โBacillus thuringiensis Cry1Ac protoxin is a potent systemic and mucosal adjuvant,โ Scandanavian Journal of Immunology 49 (1999): 578โ584. See also Vazquez-Padron et al., 147 (2000b).
[21] V. E. Prescott, et al, โTransgenic Expression of Bean r-Amylase Inhibitor in Peas Results in Altered Structure and Immunogenicity,โ Journal of Agricultural Food Chemistry (2005): 53.
[22] Arpad Pusztai, โCan science give us the tools for recognizing possible health risks of GM food,โ Nutrition and Health, 2002, Vol 16 Pp 73-84
[23] Comments to ANZFA about Applications A346, A362 and A363 from the Food Legislation and Regulation Advisory Group (FLRAG) of the Public Health Association of Australia (PHAA) on behalf of the PHAA, โFood produced from glyphosate-tolerant canola line GT73,โ http://www.iher.org.au/
[24] M. Malatesta, C. Caporaloni, S. Gavaudan, M. B. Rocchi, S. Serafini, C. Tiberi, G. Gazzanelli, โUltrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean,โ Cell Struct Funct. 27 (2002): 173โ180.
[25] M. Malatesta, C. Tiberi, B. Baldelli, S. Battistelli, E. Manuali, M. Biggiogera, โReversibility of Hepatocyte Nuclear Modifications in Mice Fed on Genetically Modified Soybean,โ Eur J Histochem, 49 (2005): 237-242.
[26] I.V. Ermakova, โDiet with the Soya Modified by Gene EPSPS CP4 Leads to Anxiety and Aggression in Rats,โ 14th European Congress of Psychiatry. Nice, France, March 4-8, 2006; โGenetically modified soy affects posterity: Results of Russian scientistsโ studies,โ REGNUM, October 12, 2005; http://www.regnum.ru/english/526651.html; Irina Ermakova, โGenetically modified soy leads to the decrease of weight and high mortality of rat pups of the first generation. Preliminary studies,โ Ecosinform 1 (2006): 4โ9.
[27] Irina Ermakova, โExperimental Evidence of GMO Hazards,โ Presentation at Scientists for a GM Free Europe, EU Parliament, Brussels, June 12, 2007
[28] L. Vecchio et al, โUltrastructural Analysis of Testes from Mice Fed on Genetically Modified Soybean,โ European Journal of Histochemistry 48, no. 4 (OctโDec 2004):449โ454.
[29] Oliveri et al., โTemporary Depression of Transcription in Mouse Pre-implantion Embryos from Mice Fed on Genetically Modified Soybean,โ 48th Symposium of the Society for Histochemistry, Lake Maggiore (Italy), September 7โ10, 2006.
[30] I.V. Ermakova, โDiet with the Soya Modified by Gene EPSPS CP4 Leads to Anxiety and Aggression in Rats,โ 14th
European Congress of Psychiatry. Nice, France, March 4-8, 2006; โGenetically modified soy affects posterity: Results of Russian scientistsโ studies,โ REGNUM, October 12, 2005; http://www.regnum.ru/english/526651.html; Irina Ermakova, โGenetically modified soy leads to the decrease of weight and high mortality of rat pups of the first generation. Preliminary studies,โ Ecosinform 1 (2006): 4โ9.
[31] โMortality in Sheep Flocks after Grazing on Bt Cotton FieldsโWarangal District, Andhra Pradeshโ Report of the Preliminary Assessment, April 2006, http://www.gmwatch.org/archive2.asp?arcid=6494
[32] Mae-Wan Ho, โGM Ban Long Overdue, Dozens Ill & Five Deaths in the Philippines,โ ISIS Press Release, June 2, 2006; and Mae-Wan Ho and Sam Burcher, โCows Ate GM Maize & Died,โ ISIS Press Release, January 13, 2004, http://www.isis.org.uk/CAGMMAD.php
[33] Personal communication with Jerry Rosman and other farmers, 2006; also reported widely in the farm press.
[34] See for example Mae-Wan Ho, โGM Ban Long Overdue, Dozens Ill & Five Deaths in the Philippines,โ ISIS Press Release, June 2, 2006; โStudy Result Not Final, Proof Bt Corn Harmful to Farmers,โ BusinessWorld, 02 Mar 2004; and โGenetically Modified Crops and Illness Linked,โ Manila Bulletin, 04 Mar 2004.
[35] Arpad Pusztai, โCan science give us the tools for recognizing possible health risks of GM food,โ Nutrition and Health, 2002, Vol 16 Pp 73-84; Stanley W. B. Ewen and Arpad Pusztai, โEffect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine,โ Lancet, 1999 Oct 16; 354 (9187): 1353-4; and Arpad Pusztai, โFacts Behind the GM Pea Controversy: Epigenetics, Transgenic Plants & Risk Assessment,โ Proceedings of the Conference, December 1st 2005 (Frankfurtam Main, Germany: Literaturhaus, 2005)
[36] Netherwood et al, โAssessing the survival of transgenic plant DNA in the human gastrointestinal tract,โ Nature Biotechnology 22 (2004): 2.
[37] Ricarda A. Steinbrecher and Jonathan R. Latham, โHorizontal gene transfer from GM crops to unrelated organisms,โ GM Science Review Meeting of the Royal Society of Edinburgh on โGM Gene Flow: Scale and Consequences for Agriculture and the Environment,โ January 27, 2003; Traavik and Heinemann, Genetic Engineering and Omitted Health Research; citing Schubbert, et al, โIngested foreign (phage M13) DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice,โ Mol Gen Genet. 242, no. 5 (1994): 495โ504; Schubbert et al, โForeign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA,โ Proc Natl Acad Sci USA 94, no. 3 (1997): 961โ6; Schubbert et al, โOn the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus,โ Mol Gen Genet. 259, no. 6 (1998): 569โ76; Hohlweg and Doerfler, โOn the fate of plants or other foreign genes upon the uptake in food or after intramuscular injection in mice,โ Mol Genet Genomics 265 (2001): 225โ233; Palka-Santani, et al., โThe gastrointestinal tract as the portal of entry for foreign macromolecules: fate of DNA and proteins,โ Mol Gen Genomics 270 (2003): 201โ215; Einspanier, et al, โThe fate of forage plant DNA in farm animals; a collaborative case-study investigating cattle and chicken fed recombinant plant material,โ Eur Food Res Technol 212 (2001): 129โ134; Klotz, et al, โDegradation and possible carry over of feed DNA monitored in pigs and poultry,โ Eur Food Res Technol 214 (2002): 271โ275; Forsman, et al, โUptake of amplifiable fragments of retrotransposon DNA from the human alimentary tract,โ Mol Gen Genomics 270 (2003): 362โ368; Chen, et al, โTransfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles,โ World Journal of Gastroenterology 10, no 1(2004): 112โ116; Phipps, et al, โDetection of transgenic and endogenous plant DNA in rumen fluid, duodenal digesta, milk, blood, and feces of lactating dairy cows,โ J Dairy Sci. 86, no. 12(2003): 4070โ8.
[38] William E. Crist, Toxic L-tryptophan: Shedding Light on a Mysterious Epidemic, http://www.seedsofdeception.com/Public/L-tryptophan/index.cfm; and Jeffrey M. Smith, Seeds of Deception, Yes! Books, Fairfield, IA 2003, chapter 4, Deadly Epidemic