Cytokine chart- for fellow geeks who really like to study their immunology
Cytokine
Sources
Principal Activities
IL-1 Activated Macrophages Pyrogen (cause fever).
Activates Endothelial cells.
Stimulatory to T-Cells.
Enhances activity of NK cells.
Provides a competence signal to allow B-Cell growth.
IL-2 Th1 & Tc cells
T cell proliferation and differentiation.
Macrophages, NK, & Tc cell activation.
Th1 autocrine growth factor.IL-4 Th2 cells B cell proliferation and differentiation,
Ig isotype switching (IgE).
Increases MHC-II on B-Cells.
Th2 autocrine growth factor.IL-5 Th2 cells B cell proliferation/differentiation,
Ig isotype switching (IgA)
Eosinophils proliferation & differentiationIL-6 Activated Mactophages,
T & B cellsPyrogen.
Promotes terminal differentiation of B cells into plasma cells. Hepatocytes: promotes Acute Phase ResponseIL-8 Activated Macrophages Chemotactic factor for many immune system cells. IL-10 Th2 cells Inhibition of Th1 cytokine synthesis.
APC: down regulates MHC-II expressionIL-12 Macrophages Promotes CTL activities.
Activate NK cellsIL-13 T-Helper cells Inhibit inflammatory response. TNF-a T cells, NK cells & Macrophages Pyrogen.
Activates Endothelial cells.
PMN & Macrophages activation. Increases MHC-I expression.
Acute Phase Response.
Cachexia & Shock.INF-g Th1 cells, NK cells. Macrophage activation,
Induction of MHC-I & -II expression.
NK cell activation.
Inhibits Th2 activity.
